Bhavani 1pg and research department of biochemistry, adhiparasakthi college of arts and science, kalavai 632506, vellore district, tn, india article info abstract article history. When gymnema leaf extract is administered to a diabetic patient, there is stimulation of the pancreas by virtue of which there is an increase in insulin release 14. Plants are well known in traditional medicine for their hypoglycaemic activities. A list of medicinal plants with proven antidiabetic and related beneficial effects and of keywords. Determination of in vitro antidiabetic effects of zingiber. Antihyperglycemic activity of compounds isolated from. Antidiabetic activity of helicteres isora root sama venkatesh1, g. It is a topical plant that is widely cultivated in assam, india for its intensly bitter fruits. Medicinal plants have been proposed as rich yet unexploited potential sources for antidiabetic drugs, even though. Momordica charantia is a flowering vine in the family cucurbitaceae. A number of active components were isolated from medicinal plants for direct use as drugs, or act as a lead compound or pharmacological agents. Many indian medicinal plants are reported to be useful in diabetes1, 2. Evaluation of in vitro anti diabetic activity of selected. Foeniculum vulgare, antidiabetic activity, aqueous extract, streptozotocininduced diabetic rats.
An update 1mohd iqbal yatoo, 2archana saxena, 3arumugam gopalakrishnan, 4mahmoud alagawany and 5kuldeep dhama 1sherekashmir university of agricultural sciences and. Antidiabetic activity of vinca rosea extracts in alloxan. Antihyperglycemic activity of compounds isolated from indian. Pdf antidiabetic effect of compounds isolated from plants. Diabetes is a complex and multifarious group of disorders characterized by hyperglycemia that has reached epidemic proportions in the present century. Department of microbiology, kakatiya university, warangal, india.
Medicinal plants with potential antidiabetic activity a. Plant species with antidiabetic properties plantbased medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. The present work was to evaluate the in vitro anti diabetic activity of methanolic extracts of cinnamomum zeylanicum, piper betle, artocarpus heterophyllus and. Medicinal plants have always been considered as healthy source of life for all peoples due to its rich therapeutic properties and being 100% natural. Most of these medicinal plants are scientifically validated for their therapeutic efficacy and safety. A number of medicinal plants extracts have showed significant hypoglycemic properties 14,15.
Several medicinal plants exhibit antidiabetic activity, among these are a few species of aloe. In vitro investigation of antidiabetic potential of. Available literature indicates that there are han 800 plants species showing hypoglycaemic activity rajagopal and sasikala, 2008. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining. Antidiabetic principles from five plants were isolated. Multiple mechanisms, due to many phytoconstituents, were documented for the antidiabetic activity of medicinal plants. Metformin, for example, is an oral hypoglycemic agent isolated from medicinal plant galega officinalis that was used historically in medieval europe for the treatment of diabetes 11. Antidiabetic activity medicinal plant aegle marmelos linn. The antidiabetic activity performed in plant is often due to the presence of phenolic acids, phenolic diterpenes, flavonoids, steroids, triterpenoids, alkaloids and other nitrogen compounds perez. Approach to phytochemistry and mechaniasm of action of. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Antidiabetic potential of two medicinal plants used in. Therefore, documenting the efficacy of antidiabetic medicinal plants has been increased, and their characterizations of chemical constituents are focused in drug discovery programmes to bring a better lead molecule to treat.
In the african region this rate is the highest, with 20 million diagnosed diabetics. An overview and future scope on traditionally used herbal. Antidiabetic effect of traditionally used medicinal plants. Recently, a large diversity of animal models has been developed to better understand the pathogenesis of diabetes mellitus and new drugs have been introduced in the market to treat this disease. Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants. An isolated fractions showing for higher anti diabetic activity was subjected to column chromatography that led to isolation of a pure compound, which was given trivial name lr1.
Evidence based antidiabetic selected indigenous medicinal. The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Antidiabetic agents from medicinal plants bentham science. There are different classes of antidiabetic drugs, and their selection depends. The efficiency of these medicinal plants may regulate the diabetic metabolic abnormalities. More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used. The fraction d from etlr was found to lower the fbg level significantly p may 02, 2017 a number of active components were isolated from medicinal plants for direct use as drugs, or act as a lead compound or pharmacological agents. Anti diabetic medicinal plants open access journals. Several drugs such as biguanides and sulfonylureas are presently available to reduce hyperglycemia. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a. Antidiabetic activity of ethanolic extract of hydnocarpus. Open access international journal of pharmacology issn 18117775 doi. Polyherbal formulations based on indian medicinal plants. In vitro investigation of antidiabetic potential of selected.
Anti diabetic medicinal plants used for diabetes mellitus maryam rahimi department of horticultural science, university of zabol, iran abstract diabetes mellitus is a group of metabolic diseases characterized by high blood sugar glucose levels, that result from defects in insulin secretion, or action, or both. Antidiabetic herbal drugs and polyherbal formulation used. An acute oral toxicity study was performed as per oecd guidelines 423. The plant kingdom possesses a wide variety of natural substances that have antidiabetic action, and have few or no documented side effects. Singab an, youssef fs, ashour ml 2014 medicinal plants with potential antidiabetic activity and their assessment. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Approximately, 108 plant species belonging to 56 families and 400 plants. It assists the researchers to understand mechanism of action, structure and potential antidiabetic activities of scientific evaluated plants. Medicinal plants used for the treatment of diabetes. Evaluation of antidiabetic activity of ipomoea aquatica. Antidiabetic activity and phytochemical screening of. Among active medicinal herbs, momordica charantia l.
Globally, medicinal plants have been used as a source of medicine and 8085% of populations rely on these medicinal plants using the extracts or their active components as traditional medicine to meet their primary health care needs 9, 10. The literature was surveyed to find distribution, chemical constituents and other medicinal uses of these plants. Total 74 various medicinal plants are found mentioned in. Introduction in folk medicinal practice many plants are used to treat diabetes mellitus in south india. Antidiabetic effect of medicinal plants aegle marmelos it belongs to family rutaceae and is a midsized, slender. The hypoglycemic effect of several plants used as antidiabetic remedies has been confirmed, and the mechanisms of hypoglycemic activity of these plants are being studied. Results and discussion antidiabetic herbs mentioned in various ayurvedic nighantus are compiled and detailed along with their scientific nomenclatures in table 1 3. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in nondiabetic subjects and the same result was seen in diabetic subjects. Antidiabetic activity medicinal plant aegle marmelos. Department of environmental science and technology, jntu, hyderabad 2. Leguminosae have been reported as beneficial for treatment of type 2 diabetes. This study aims at determining the anidiabetic potential of five traditional medicinal plants such as, sarcostemma brevistigma, grewia hirsuta, indigofera aspalathoides, memecylon edule and solanum trilobatum. Antidiabetic activity of the compounds isolated from.
Antidiabetic activity of the compounds isolated from rhus mysorensis plant extract ganji renuka rani 1,2, singara charya ma2, m. Antidiabetic medicinal plants gymnema sylvestre gymnema sylvestre has long been used as a treatment for diabetes 11. Animal models to test drugs with potential antidiabetic activity. The world health organization who has listed 21,000 plants, which are used for medicinal purposes around the world. Pulla reddy college of pharmacy, mehdipatnam, hyderabad 500 028.
Isolation and characterization of antidiabetic compound. In vitro antiglycation activity of some medicinal plants used in diabetes mellitus. Acute toxic class method is a stepwise procedure with use of three animals of a single sex per step. Andiabetic activity ofnymphaea pubescens willda plant drug of aquatic flora interest. The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using. Medicinal plants were assessed for their antidiabetic activity, but these plants. Mechanism of action for the drug class inhibition of dpp4 enhances the activity of active glp1, thus increasing glucosedependent insulin secretion and. Despite of the fact that there are several herbal medicines are available in the market, search for much effective drug of plant origin will continue 3. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Here we enlisting table 1 some of the medicinal plants with potential antidiabetic activities reported with their possible mode of action table 2.
By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. Antidiabetic activity of nymphaea pubescens ethanolic. Promising antidiabetic drugs, medicinal plants and herbs. In vivo and in vitro antidiabetic activity of terminalia. The medicinal plants produce antidiabetic activity due to presence of tannin, saponins, alkaloid, glycoside, polyphenol and flavonoids etc. Many of the synthetic drugs were discovered either directly. Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. Determination of in vitro antidiabetic effects of zingiber officinale roscoe 603 glucose diffusion inhibition the potential of ginger rhizome extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. Plant name part used possible mechanism of action references. Antidiabetic activity of medicinal plants and its relationship with their antioxidant property. Blume was selected which was traditionally used for various ailments like leprosy, antioxidant, secondary syphilis, rheumatism ophthalmic, the folklore claim of hydnocarpus wightiana blume shows that it is having antioxidant properties and antidiabetic activity.
Among 1200 plants which possess hypoglycemic property, only 30% of the antidiabetic plants have been pharmacologically tested and investigated plant constituents with antidiabetic activity dietary fibers, flavonois, alkaloids, saponins, amino. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. Diabetes mellitus, hypoglycemic, antidiabetic plants introduction medicinal plants have always been considered as healthy source of life for all people due to its rich in therapeutic properties and being 100% natural 1. Antidiabetic activity of nymphaea pubescens ethanolic extract. Previous reports showed antidiabetic activity of aloe extract kuraev et al. Studies for antidiabetic activity in alloxanized mice in our laboratory showed.
Family sterculiaceae is a shrub or small tree available in forests from bengal to ceylon. Medicinal and natural herbal plant products are traditionally used from long time in many countries for the treatment of diabetes mellitus. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Potential antidiabetic activity of medicinal plants a. Although medicinal plants have been historically used for diabetes treatment throughout the world, few of them have been validated by scientific criteria. Approach to phytochemistry and mechaniasm of action of plants. It is a topical plant that is widely cultivated in assam, india for its intensly bitter fruits that are commonly used in cooking and as. Jul 14, 20 multiple mechanisms, due to many phytoconstituents, were documented for the antidiabetic activity of medicinal plants.